Leopoldo Santos-Argumedo PhD


Principal researcher 3E

National Research System: III

Ph. D. in Immunology (1989), National School of Biological Sciences (ENCB), at the National Polytechnic Institute (IPN).

Tel: +52 (55) 5747-3323 (office)
       +52 (55) 5747-3800 ext: 5020 (lab)



Dr. Leopoldo Santos-Argumedo is the principal investigator and head of the Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (https://www.cinvestav.mx). He has a degree (Microbiology) from the National School of Biological Sciences (ENCB-IPN) (1980); Master's (1985) and Doctorate (1989), both specializing in Immunology, from the ENCB, IPN. He did postdoctoral studies at the Department of Immunology, National Institute for Medical Research, Mill Hill, London, UK (1989-1991). In the Department of Immunology, DNAX Research Institute, Palo Alto Cal., USA (1991-1993). He has supervised 29 doctoral theses and 44 master's theses. He is the author of more than one hundred articles in JCR indexed journals with more than 2500 citations. His research interest is focused on studying the activation, maturation, and differentiation mechanisms of B lymphocytes in humans and mice. In recent years his work has focused on searching for the role of class I myosins in the immune response. His laboratory has been analyzing the molecular mechanisms in human primary immunodeficiencies for more than a decade; he also works in IgA's characterization and the microbiome in human colostrum. He has served as president of the Mexican Society of Immunology (SMI) (2002-2004) and of the Latin American Association of Immunology (ALAI) (2015-2018). He has also served on the International Union of Immunological Societies (IUIS) (2015-2018). He is currently a member of the publications committee and was again elected to the IUIS council (2019-2022). He is a full member of various scientific associations, among which the Mexican Society of Immunology, the Mexican Academy of Sciences, the National Academy of Medicine, the Society for Leukocyte Biology (SLB), the American Association for the Advancement of Science (AAAS) and the American Association of Immunologists (AAI).




  • Bachelor's Degree: Bacteriologist and Parasitologist Chemist, ENCB, IPN. (1980). Master of Science: Immunology. ENCB, IPN. (1985). Ph.D.: Immunology. ENCB, IPN. (1989)

  • Postdoctoral stays: Department of Immunology of the National Institute for Medical Research, Mill Hill, London UK. In the laboratory of Dr. R.M.E. Parkhouse. (1989-1991). Department of Immunology of the DNAX Research Institute, Palo Alto Cal., USA. In Dr. Maureen Howard's lab. (1991-1993)

  • Level III of the National Research System (2018-2028)

  • Sabbatical leave at Immunogenetics Laboratory of the National Institute of Allergy and Infectious Diseases, NIH, MD, USA. In the laboratory of Dr. Susan k. Pierce (2004-2006)

  • Experience in research and teaching: Department of Immunology of the National School of Biological Sciences, IPN. (From September 1980 to October 1993). Iztacala School of Higher Studies, UNAM. (1982 and 1983). Infectology Department. National Institute of Pediatrics, SSA. (From 1983-1986). Cell Biology Department, CINVESTAV-IPN. (October 1993 to March 30, 1999). Department of Molecular Biomedicine, CINVESTAV-IPN. From the 1st. April 1999 to date), (Current Category: Cinvestav-3E Researcher)

  • Field of specialization: Immunology

  • Research articles published: 128 (March 23, 2021)

  • (https://pubmed.ncbi.nlm.nih.gov/?term=santos-argumedo+l&sort=date&size=200)

  • Thesis Direction. Doctorate: 29. Master's: 44. Bachelor's: 15.


Myosins are a family of motor proteins whose role in muscle contraction and mobility in a wide range of eukaryotic cells has been extensively studied. These proteins have been extensively characterized. Much is known about their function in different cell types; little is known about these molecules in hematopoietic cells. The myosins expressed by the immune response cells participate in maintaining the tension of the plasma membrane, in the transport of secretory vesicles, in the endo and exocytosis processes, and in promoting adherence and motility of the cells. In the laboratory, we are interested in understanding the role of class 1 myosins in lymphocytes, emphasizing the emerging role of these molecular motors in the functions of the immune response.

Primary immunodeficiencies (PID) are a diverse group of more than 300 genetic disorders that fundamentally affect the immune system's development and functionality. Most of them are monogenic disorders, but the spectrum of PIDs is constantly expanding to identify new immunodeficiency syndromes through the generation of sequencing technologies and better clinical knowledge. Patients classically present with increased susceptibility to infections or infections by unusual microorganisms may also develop autoimmunity or autoinflammatory disease and neoplasms. Although supportive treatments are effective for many of these conditions, the more serious ones require early definitive treatment using a hematopoietic stem cell transplant to prevent chronic morbidity and premature mortality. The study of these conditions in Mexico is developing. Our group (made up mainly of researchers from the National Institute of Pediatrics and our laboratory) has taken on the task of identifying and characterizing both clinically and molecularly these patients. We hope to contribute with these studies to a better diagnosis, which may result in a timely and better-targeted treatment; Additionally, we hope to learn from these patients the molecular determinants that control the immune system's various functions in a natural environment. Using a complementary approach, we studied mice deficient in some of the molecules described as causing PIDs to better understand their role.

The immunological experience that the mother has accumulated plays an essential role in protecting the newborn through the maternal transfer of IgA present in colostrum and milk. Most of the area's work has been limited to determining total IgA levels without differentiating between IgA1 and IgA2. In our laboratory, we have given ourselves the task of quantifying the levels of immunoglobulins in Mexican mothers' colostrum, using the quantitative ELISA technique, with emphasis on the levels of IgA1 and IgA2. The results so far indicate a correlation between the levels of IgA1 in the colostrum of women with respiratory tract and skin infections. In contrast, IgA2 was elevated in the colostrum of women who had gastrointestinal tract infections during pregnancy.

In conclusion, the presence of infections during pregnancy increases the levels of IgA in colostrum. This increase is dependent on the site of induction of the response, being different between the respiratory mucosa, where the response by IgA1 predominates in colostrum, and the digestive mucosa, where the increase observed is with IgA2. These data provide evidence to understand the effect of immunizations and infections during pregnancy that a clinically healthy woman can usually present. This information gives us an idea of the possible effects it would have on protecting the newborn and the individual role of IgA subtypes in maternal transfer. More recently, we have begun studying the colostrum microbiota and its association with IgA, looking for how these antibodies can impact the establishment of the newborn's intestinal microbiota.

Finally, derived from the COVID-19 pandemic, we have established quantitative methods to evaluate the presence of antibodies against this virus, seeking to contribute to the diagnosis and a better understanding of immunity in this disease.


https://www.facebook.com/INCICh.edu/videos/1199810900411209/ (May 27th, 2020)
https://youtu.be/eGq3BpjfbGY (July 8th, 2020)
https://youtu.be/4w9pSuPGvN8 (July 13th, 2020)
https://youtu.be/8Zf1Hn-ollM (November 16th, 2020)
https://youtu.be/ylgLGgcMLSI (February 17th, 2021)
https://avanceyperspectiva.cinvestav.mx/author/leopoldo-santos-argumedo/ (March 13th, 2021)

Carlos Emilio Miguel Rodríguez
Degree: Pharmaceutical Chemist-Biologist, Faculty of Chemical Sciences, Universidad Veracruzana, Orizaba Veracruz.
Master of Science, specialty in Infectomics and Molecular Pathogenesis. Cinvestav Zacatenco. CDMX
Project: Participation of myosin 1g (myo1g) during the infection process of murine norovirus type 1 (mnv-1) in B lymphocytes.

Diana Olguín Calderón
Bachelor's Degree in Pharmaceutical Chemistry-Biologist, Autonomous University of Zacatecas, Zacatecas, Mexico.
Master of Science, specialty in Molecular Biology, IPICYT, San Luis Potosí, Mexico.
Project: Functional evaluation of B cells in response to IL-21 in patients with Common Variable Immunodeficiency.

José Mizael Flores Hermenegildo
Bachelor's Degree: Chemist Bacteriologist Parasitologist, National School of Biological Sciences, IPN
Master of Science in Immunology, National School of Biological Sciences, IPN
Project: Participation of Lrba in the change of isotype to IgA in murine B lymphocytes.

David Cruz Zárate
Bachelor's Degree: Chemist-Biologist, UABJO-Oaxaca.
Master of Science in Immunology, ENCB-IPN.
Project: Functional characterization of myosin 1g during the antigenic presentation of B lymphocyte.

Irving Ulises Martínez Vargas
Bachelor's Degree: Pharmaceutical Chemistry-Biologist, Higher School of Natural Sciences. UAGro.
Master of Science, specialty in Infectomics and Molecular Pathogenesis. Cinvestav Zacatenco. CDMX
Project: "Participation of long-tailed class I myosins in the migration of intestinal intraepithelial T?? lymphocytes."

Erick Saúl Sánchez Salguero
Bachelor's Degree: Pharmaceutical Chemistry-Biologist, FESC, UNAM.
Master of Science, Specialty in Molecular Biomedicine, CINVESTAV Zacatenco Unit.
Project: Association of human colostrum IgA subclasses and their effect on the newborn's composition of the microbiota.

Héctor Romero Ramírez
Biologist Pharmaceutical Chemist. FES Cuautitlán, UNAM.
Master of Science, specialty in Immunology, National School of Biological Sciences, IPN.
Ph.D. in science, specialty in Immunology
National School of Biological Sciences, IPN.

Lenin Estudillo Díaz

Nombre Institución Email
Zendejas Buitrón Victor Manuel Universidad Nacional Autónoma de México victorzend61@aol.com
Guerra Infante Fernando Mar Instituto Nacional de Perinatología fguerra_96@yahoo.com
Valdés Ramos Roxana Universidad Autónoma del Estado de México rvaldesr@uaemex.mx
Moreno Lafont Martha Escuela Nacional de Ciencias Biológicas mmlafont@gmail.com
Garibay Escobar Adriana Universidad de Sonora agaribay@guayacan.uson.mx
Partida Sánchez Santiago Nationwide Children's Hospital in Columbus, Ohio santiago.partida-sanchez@nationwidechildrens.org
Moyrón Quiroz Juan Enrique Biolegend, San Diego CA. jmoyron@biolegend.com
Pedraza Sánchez Sigifredo Instituto Nacional de Ciencias Médicas y Nutrición spedraza@rocketmail.com
Moreno García Miguel Enrique Boehringer Ingelheim Pharmaceuticals, Inc miguel.moreno-garcia@boehringer-ingelheim.com
Moreno García Miguel Enrique Boehringer Ingelheim Pharmaceuticals, Inc miguel.moreno-garcia@boehringer-ingelheim.com
Sumoza Toledo Adriana Universidad Veracruzana asumoza@uv.mx
Sandoval Montes Claudia Escuela Nacional de Ciencias Biológicas claudiaqfb@yahoo.com
Álvarez Zavala Bertha Judith Instituto Nacional de Ciencias Médicas y Nutrición bertha_alvarez@yahoo.com
Manjarrez Orduño Nataly Bristol Myers Squibb, Scientist nataly.manjarrez@gmail.com
López Herrera Gabriela Instituto Nacional de Pediatría lohegabyqbp@yahoo.com.mx
Rodríguez Alba Juan Carlos Universidad Veracruzana jcra19@yahoo.com
Berrón Ruíz Laura Instituto Nacional de Pediatría lberronruiz@yahoo.com.mx
Maravillas Montero José Luis Red de Apoyo a la Investigación; CIC, UNAM maravillas@cic.unam.mx
Vargas Hernández Alexander Baylor College of Medicine alexander.vargas-hernandez@bcm.edu
Vences Catalán Felipe Stanford University fvences5@stanford.edu
Mita Mendoza Neida Karen National Institute of Allergy and Infectious Diseases, NIH mitamendozan@niaid.nih.gov
Romero Ramírez Héctor Departamento de Biomedicina Molecular. Centro de Investigación y de Estudios Avanzados del IPN hromero@cinvestav.mx
Ramírez Alejo Noé Bristol Myers Squibb, Scientist noe.ramirez.alejo@gmail.com
Alcántara Montiel Julio César Facultad de Estudios Superiores Zaragoza UNAM dr.jcalcantara@gmail.com
López Ortega Orestes Institut National de la Santé et de la Recherche Médicale (INSERM) U1151, Institut Necker Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France olopezortega@outlook.com
Pérez Martínez César Augusto Radboud University Medical Center cesar.perez-martinez@radboudumc.nl
Domínguez Pantoja Marilú Facultad de Nutrición de la Universidad Veracruzana & Facultad de Medicina de la Universidad Anáhuac marildominguez@uv.mx
Piedra Quintero Zayda Lizbeth The Ohio State University, Investigador postdoctoral zpiedra85@gmail.com
Daniel Alberto Girón Pérez Universidad Autónoma de Nayarit, Centro Nayarita de Innovación y Transferencia de Tecnología A.C.
(CENITT), Laboratorio Nacional para la Investigación e Inocuidad Alimentaria (LANIIA Unidad Nayarit
Nidia Carolina Moreno Postdoctoral fellow at Laboratory or Human Lymphohematopoiesis, Imagine Institute, INSERM UMR 1163, Université de Paris, Paris, France nmorenoc@cinvestav.mx