Leticia Cedillo Barrón PhD

3C Senior Researcher
Category in the SNI: Level II
Doctor of Science in Immunology (1994), ENCB, IPN


Dr Leticia Cedillo-Barrón is a Bacteriologist and Parasitologist, specialist in Virology and Immunology. She obtained a Master and PhD in Immunology doing research in Malaria and lecturing at the National School of Biological Sciences (ENCB-IPN). She then joined the team of Professor Michael Parkhouse at the Institute for Animal Health in Pirbrigh (UK) obtaining first a fellowship from the Wellcome foundation for two years. She then got her training in Virology and Molecular Biology with the exotic viruses such as FMDV and ASF. After, she was hired by the European Community at the same institution for 4 years, when she was involved in the evaluation of different targets of protective immunogens for the elaboration of potential recombinant vaccines. Currently she is working at CINVESTAV since the year 2000. Level II of the SNI (2014-)

  • Research articles published: 51

  • Chapters in books 4

  • Direction of Doctoral Thesis: 14.

  • Direction of Master Thesis: 20

  • Direction of Bachelor Thesis: 1


  • Dengue virus and its proteins involved in immunopathogenesis.

  • Innate immunity against Dengue, Zika and CHIKV viruses.

  • Recombinant vaccines against Dengue virus. Research and teaching experience


In our laboratory, we are interested in Characterization of the early events involved in innate immunity against Dengue virus.
Is well known that DENV can trigger apoptosis in host cells in vitro and in vivo. We are interested to elucidate the viral proteins and the mechanisms by which DENV trigger apoptosis. The elucidation of this phenomena may be critical to understand dengue pathogenesis in the early times of infection
Additionally, we are studying the immune responses in animal models and also in patients from Dengue outbreaks in different regions of Mexico.


1987-1999 Assistant Professor of Immunology at Immunology department. National School of Biological Science -IPN
1994-2000 Posdoctoral Research Fellow. Institute for animal Health Pirbright Laboratory Surrey  UK
2000- Senior Research at Centro de Investigacion y estudios Avanzados. Depto of Molecular Biomedicine  (lecturer and researcher)


Advanced Virology (for Postgraduate Students)
Immunology (For Posgraduate Students)

Center for Research and Advanced Studies as a Researcher. • Level II of the SNI (2014-) • Research articles published: 51 • Chapters in books 4 • Direction of Doctoral Thesis: 14. • Direction of Master's Thesis: 20 • Direction of Bachelor's Thesis: 1 Research topics • Dengue virus immunopathogenesis. • Innate immunity against Dengue, Zika and CHIKV viruses. • Recombinant vaccines against Dengue virus. Research and teaching experience • Associate Professor C. Department of Immunology National School of Biological Sciences IPN (1988-1994). • Postdoctoral stay Department of Immunology Institute for Animal Health (IAH Pirbright Laboratory) Surrey County UK (1994-2000) • Department of Molecular Biomedicine CINVESTAV-IPN from July 200 to date.

Colaboration Institutes
Dr. Francisco Juárez Delgado Hospital Santa Maria Ticomán (National Health System)
Dr. Héctor Vivanco Cid Universidad Veracruzana
Dr. Philipe Despres Pasteur Institute. France
Dr. Leopoldo Santos Biomedicina Molecular (CINVESTAV)
Dr. Leopoldo Flores Romo Cellular Biology (CINVESTAV)
Dr. Samuel Canizales Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Dr. Miguel Ángel Gómez-Lim CINVESTAV- (Campus Guanajuato)
Dr. José Bustos Arriaga Universidad Nacional Autónoma de México
Dr. Stephen S. Whitehead National Institutes of Health USA
Dr. Humberto Lanz Mendoza Instituto Nacional de Salud Pública
Dr. Jesús Valenzuela National Institutes of Health USA
Dr. Moisés León Juárez Instituto Nacional de Perinatología
Dr. José Luis Maravillas Instituto Nacional de Pediatria
Dr. Edgar Morales CINVESTAV-Zacatenco
Dr. Juan Manuel Alvarado Orozco CIDECI
Dr. David Fernández Benavidez CIDECI
  • Montes-Gómez AE, García-Cordero J, Marcial-Juárez E, Shrivastava G, Visoso-Carvajal G, Juárez-Delgado FJ, Flores-Romo L, Sanchez-Torres MC, Santos-Argumedo L, Bustos-Arriaga J, Cedillo-Barrón L. Crosstalk Between Dermal Fibroblasts and Dendritic Cells During Dengue Virus Infection. Front Immunol. 2020 Oct 23;11:538240. doi: 10.3389/fimmu.2020.538240. eCollection 2020.

  • Marcial-Juárez E, García-Cordero J, Maqueda-Alfaro RA, Saucedo-López RE, Sánchez-Torres LE, Cedillo-Barrón L, Flores-Romo L. Cutaneous Dengue Virus Inoculation Triggers Strong B Cell Reactions but Contrastingly Poor T Cell Responses. Virol Sin. 2020 Oct;35(5):575-587. doi: 10.1007/s12250-020-00213-6.

  • Shrivastava G, Visoso-Carvajal G, Garcia-Cordero J, Leon-Juarez M, Chavez-Munguia B, Lopez T, Nava P, Villegas-Sepulveda N, Cedillo-Barron L. Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. Front Immunol. 2020 Mar 10;11:352. doi:10.3389/fimmu.2020.00352.

  • Montecillo-Aguado MR, Montes-Gómez AE, García-Cordero J, Corzo-Gómez J, Vivanco-Cid H, Mellado-Sánchez G, Muñoz-Medina JE, Gutiérrez-Castañeda B, Santos-Argumedo L, González-Bonilla C, Cedillo-Barrón L. Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population. J Immunol Res. 2019 Sep 2;2019:7239347. doi: 10.1155/2019/7239347.

  • Zaidi MB, Cedillo-Barron L, González Y Almeida ME, Garcia-Cordero J, Campos FD, Namorado-Tonix K, Perez F. Serological tests reveal significant cross-reactive human antibody responses to Zika and Dengue viruses in the Mexican population. Acta Trop. 2020 Jan;201:105201. doi: 10.1016/j.actatropica.2019.105201.

  • Corzo-Gómez J, García-Cordero J, Montes Gómez AE, Bernal-Siria K, Namorado-Tónix K, Gutierrez-Castañeda B, Cedillo-Barrón L. Expression and purification of domain III proteins from Dengue and Zika viruses. Protein Expr Purif. 2019 Oct;162:38-43. doi: 10.1016/j.pep.2019.05.005

  • Serrano C, Galán S, Rubio JF, Candelario-Martínez A, Montes-Gómez AE, Chánez-Paredes S, Cedillo-Barrón L, Schnoor M, Meraz-Ríos MA, Villegas-Sepúlveda N, Ortiz-Navarrete V, Nava P Compartmentalized Response of IL-6/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development. J Immunol. 2019 Feb 15;202(4):1239-1249. doi: 10.4049/jimmunol.1801060.

  • López-González M, Meza-Sánchez D, García-Cordero J, Bustos-Arriaga J, Vélez-Del Valle C, Marsch-Moreno M, Castro-Jiménez T, Flores-Romo L, Santos-Argumedo L, Gutiérrez-Castañeda B, Cedillo-Barrón L. Human keratinocyte cultures (HaCaT) can be infected by DENV, triggering innate immune responses that include IFN? and LL37. Immunobiology. 2018 Nov;223(11):608-617. doi: 10.1016/j.imbio.2018.07.006.

  • Zaidi MB, Garcia-Cordero J, Rivero-Gomez R, Corzo-Gomez J, González Y Almeida ME, Bonilla-Moreno R, Bustos-Arriaga J, Villegas-Sepulveda N, Flores-Romo L, Cedillo-Barron L. Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants. Parasit Vectors. 2018 Jul 3;11(1):378. doi: 10.1186/s13071-018-2942-1..

  • Cedillo-Barrón L, García-Cordero J, Shrivastava G, Carrillo-Halfon S, León-Juárez M, Bustos Arriaga J, León Valenzuela P, Gutiérrez Castañeda B. The Role of Flaviviral Proteins in the Induction of Innate Immunity. Subcell Biochem. 2018;88:407-442. doi: 10.1007/978-981-10-8456-0_17..

  • Bustos-Arriaga J, Gromowski GD, Tsetsarkin KA, Firestone CY, Castro-Jiménez T, Pletnev AG, Cedillo-Barrón L, Whitehead SS. Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4?30 increases viral susceptibility to type I interferon. Vaccine. 2018 Jun 7;36(24):3460-3467. doi: 10.1016/j.vaccine.2018.04.087.

  • Vaisman CE, Del Moral-Hernandez O, Moreno-Campuzano S, Aréchaga-Ocampo E, Bonilla-Moreno R, Garcia-Aguiar I, Cedillo-Barron L, Berumen J, Nava P, Villegas-Sepúlveda N. C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis. Virus Res. 2018 Mar 2;247:94-101. doi: 10.1016/j.virusres.2018.02.009.

  • Shrivastava G, García-Cordero J, León-Juárez M, Oza G, Tapia-Ramírez J, Villegas-Sepulveda N, Cedillo-Barrón L.NS2A comprises a putative viroporin of Dengue virus 2. Virulence. 2017 Oct 3;8(7):1450-1456. doi: 10.1080/21505594.2017.1356540.

  • Montes-Gómez AE, Vivanco-Cid H, Bustos-Arriaga J, Zaidi MB, Garcia-Machorro J, Gutierrez-Castañeda B, Cedillo-Barron L. Construct and expression of recombinant domains I/II of dengue virus- 2 and its efficacy to evaluate immune response in endemic area: Possible use in prognosis.Acta Trop. 2017 Jul;171:233-238. doi: 10.1016/j.actatropica.2017.04.006.

  • Izaguirre-Hernández IY, Mellado-Sánchez G, Mondragón-Vásquez K, Thomas-Dupont P, Sánchez-Vargas LA, Hernández-Flores KG, Mendoza-Barrera C, Altuzar V, Cedillo-Barrón L, Hernández-Flores KG, Mendoza-Barrera C, Altuzar V, Cedillo-Barrón L, Vivanco-Cid H. Non-Conjugated Chitosan-Based Nanoparticles to Proteic Antigens Elicit Similar Humoral Immune Responses to Those Obtained with Alum. J Nanosci Nanotechnol. 2017 Jan;17(1):846-52. doi: 10.1166/jnn.2017.13067.

Gabriela Mellado ENCB melladosg@gmail.com
Rosendo Luria Pérez Hospital Infantil IMSS rluria77@gmail.com
Melina Vásquez Ochoa    
Jazmín García Machorro Escuela Superior de Medicina Instituto Politécnico Nacional jazzgama@hotmail
José Bustos Arriaga FESI/ UNAM jose.bustos@iztacala.unam.mx
Moisés León Juárez Instituto Nacional de Perinatología moisesleoninper@gmail.com
Juan Carlos Yam Puc University of Cambridge jcyampuc@gmail.com
Moisés González López Rutgers University  
Gaurav Shrivastava National Institute of Allergy and Infectious Diseases National Institutes of Health gaurav.shrivastava@nih.gov
Paola C Leon Valenzuela National Institute of Allergy and Infectious Diseases National Institutes of Health paolacarolina.valenzuelaleon@nih.gov
Sofia Carillo Halfon    
Edith Macias    
Alfredo Montes Gómez    
Josselin Corzo Gómez    

Dr. Leticia Cedilla Barrón
Research Professor

Dr. Julio García Cordero
Research Assistant

Froilán Ramírez Gómez
Laboratory Technician

M. Giovani Visoso Carvajal
Doctorate Student

M. Verónica Perrusquilla
Doctorate Student

M. Víctor Javier Cruz Holguín
Doctorate Student

QFB Juvenal Mendoza Ramírez
Master's Degree Student

Medic Sandra Paola Martínez Frias
Master's Degree Student

Rosendo Luria Pérez. CINVESTAV-IPN, Febrero 2007.
Hospital Infantil de México Federico Gómez
Calle Dr. Márquez No.162, Cuauhtémoc, Doctores, 06720 Ciudad de México. 01 (55) 52289917 Ext. 2129
Investigador en Ciencias Médicas C Nivel del SNI 1. rluria77@gmail.com
Gabriela Mellado ENCB-CINVESTAV-IPN Agosto 2008
Unidad de desarrollo e Investigación en Bioprocesos (UDIBI)
ENCB-IPN Prolongación de Carpio y Plan de Ayala S/N, Col. Sto. Tomas, CP 11340, CD. México, Tel 5557295000/62543 o 62584.
Responsable Sanitario y del área de investigación Básica y servicios académicos Nivel SNI 1 gmellados@ipn.mx
Jazmín García Machorro. CINVESTAV-IPN, Noviembre 2011.
Escuela Superior de Medicina IPN.
Av. Salvador Díaz Mirón s/n, esq. Plan de San Luís, Col. Casco de Santo Tomás, 11340, Ciudad de México. 01 (55) 57296000 Ext. 62753
Profesor Investigador Nivel SNI 1jazzgama@hotmail.com
José Bustos Arriaga. CINVESTAV-IPN 17 de Agosto 2012
Facultad de Estudios Superiores Campus Iztacala Unidad de Investigación en Biomedicina (UBIMED).
Avenida de los Barrios 1, Colonia Los Reyes Iztacala Tlalnepantla, Estado de México, C.P. 54090 015556231333
Profesor Investigador SNI 1 jose.bustos@iztacala.unam.mx
Moisés León Juárez. CINVESTAV-IPN, Agosto 2013.
Instituto Nacional de Perinatología Isidro Espinosa de los Reyes
Calle Montes Urales 800, Miguel Hidalgo, Lomas Virreyes, 11000 Ciudad de México. 01 (55) 5520 9900 Ext. 438
Investigador en Ciencias Médicas C Nivel SNI 1 moisesleoninper@gmail.com
Moisés López González. CINVESTAV, Agosto 2014
Regional Bio-containment Laboratory & Public Health Research Institute Center for COVID-19 New Jersey Medical School Rutgers, The State University of New Jersey 225
Warren Street, Newark, NJ 07103-3535 (973) 854-3100 Email: Posdoctoral Research. moises.lopez.gonzalez85@gmail.com
Juan Carlos Yam Puc (Co-tutoria Dr. Leopoldo Flores Romo) CINVESTAV Agosto de 2015
MRC toxicology Unit Tennis Court Road Cambridge CB2 1QR Reino Unido jcyampuc@gmail.com
Posdoctoral Nivel SNI 1
Gaurav Shrivastava CINVESTAV-IPN Agosto 2017
Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health 12735
Twinbrook Parkway TW3/2W09 Rockville 20852, Maryland Telephone: 301-761-7272 Posdoctoral Fellow. gaurav.shrivastava@nih.gov
Paola Valenzuela León CINVESTAV-IPN Octubre 2019
Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health
12735 Twinbrook Parkway TW3/2W09 Rockville 20852, Maryland Telephone: 301-761-7272 Posdoctoral Fellow
Josselin C. Corzo Gómez CINVESTAV-IPN Febrero 2019
Universidad Autónoma de Chiapas
Blvd. Belisario Domínguez Km.1081, Sin Nombre, Terán, 29050 Tuxtla Gutiérrez, Chis. Tel: 961 617 8000 Posdoctoral josselin.corzo@gmail.com
Edith Marcial Juárez CINVESTAV-IPN (co-tutoria Dr. Leopoldo Flores Romo) Enero 2020.
Royal Society Newton International Fellow Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Tel. +44 7467 039490 Posdoctoral e.marcialjuarez@bham.ac.uk
Alfredo Gómez Montes CINVESTAV-IPN Febrero 2020
Cancer Research UK Beatson Institute Institute of Cancer Sciences University of Glasgow Garscube Estate Switchback Road Glasgow
G61 1BD United Kingdom Tel: + 44 (0) 141 330 8703 Research Assistant. Alfredo.MontesGomez@glasgow.ac.uk